Your Menstrual Cycle & Your Vaginal Microbiome: How Hormones Impact Your Risk of Infection

If you keep getting vaginal infections, you might be wondering if your hormones are to blame...

your-menstrual-cycle-your-vaginal-microbiome-how-hormones-impact-your-risk-of-infection

A rich text element can be used with static or dynamic content. For static content, just drop it into any page and begin editing. For dynamic content, add a rich text field to any collection and then connect a rich text element to that field in the settings panel. Voila!

How to customize formatting for each rich text

Headings, paragraphs, blockquotes, figures, images, and figure captions can all be styled after a class is added to the rich text element using the "When inside of" nested selector system.

Your Menstrual Cycle & Your Vaginal Microbiome: How Hormones Impact Your Risk of Infection

If you keep getting vaginal infections, you might be wondering if your hormones are to blame...

While mood swings and acne are the more obvious signs of hormonal changes, their impact on your vaginal health often goes unnoticed. The truth? Your menstrual cycle has a direct effect on your vaginal microbiome and risk of infection.

In this article, we’ll explore how your microbiome changes with your cycle, when you’re likely to be more vulnerable to infections, and why oestrogen is a key player in your vaginal health.

What Is the Vaginal Microbiome?

Your vaginal microbiome is an invisible ecosystem made up of trillions of bacteria and other microorganisms. It’s constantly changing, working to strike a healthy balance between ‘helpful’ and ‘harmful’ bacteria. 

Lactobacilli are the dominant ‘helpful’ bacteria in your vaginal microbiome. A well-balanced microbiome with plenty of Lactobacilli helps protect against infections like sexually transmitted infections (STIs), Bacterial Vaginosis (BV) and Vulvo Vaginal Candidiasis (also known as thrush or a yeast infection).

Why Are Lactobacilli So Important? 

Lactobacilli are the unsung heroes of your vaginal microbiome. They work hard to keep harmful bacteria in check by: 

  • Maintaining the pH: They produce lactic acid, keeping the vaginal pH between 3.8-4.5 (mildly acidic) to prevent harmful bacteria from thriving.

  • Outcompeting: They absorb nutrients, starving harmful bacteria and stopping them from overgrowing.

  • Fighting Bacteria: They release bacteriocins, tiny proteins that kill or inhibit harmful bacteria.

  • Building a Barrier: They form a protective shield that stops harmful bacteria from sticking to the vaginal walls.

A healthy vaginal microbiome has a strong Lactobacilli population. When their levels drop, harmful bacteria can take over, leading to dysbiosis and an increased risk of infection.  

Which Hormones Impact My Vaginal Microbiome?

Hormones are chemical messengers that regulate almost every function in your body. Oestrogen and progesterone are the key hormones in your menstrual cycle, working together to prepare your body for potential pregnancy.

Oestrogen

When it comes to vaginal health, oestrogen supports your vagina in two vital ways:

  1. Tissue health: keeping your vaginal wall tissue thick, moist and elastic.
  2. Microbiome balance: supporting the protective bacteria (Lactobacilli) that prevent infection. 

Oestrogen increases the production of a sugar called glycogen in the vagina, which feeds Lactobacilli and helps them thrive

  • High oestrogen levels (like around ovulation and during pregnancy) encourage Lactobacilli growth, keeping your microbiome balanced. 
  • Low oestrogen levels (like during menstruation and menopause) reduce glycogen, making it harder for Lactobacilli to survive and easier for harmful bacteria to take over. 

It’s all about balance when it comes to your vaginal microbiome.

A healthy level of oestrogen supports Lactobacilli to thrive, but too much can trigger an overgrowth of Candida, the fungus responsible for vulvovaginal candidiasis (VVC, also known as thrush or yeast infections). Yeast infections are particularly common during pregnancy when oestrogen levels are high.

Progesterone

Progesterone, on the other hand, may have the opposite effect. Research suggests that higher progesterone levels in the luteal phase can lower glycogen availability. This can reduce Lactobacilli levels, creating an environment where infection is more likely to take hold.  

How Does My Vaginal Microbiome Change With My Cycle?

Your menstrual cycle is about so much more than your period. Many of the changes are more subtle, including the ones to your vaginal microbiome. As your hormone levels rise and fall throughout your cycle, they influence which bacteria thrive in your vagina and how susceptible you are to infection.

Menstrual Phase (Days 1-5)

  • Hormonal changes: Oestrogen and progesterone levels are at their lowest as you shed your uterine lining.

  • Microbiome impact: Lactobacilli levels drop and your vaginal pH also rises due to menstrual blood (which has a neutral pH).

  • Infection risk: Your risk of infection may be higher due to fewer protective Lactobacilli and increased bacterial diversity.

Follicular Phase (Days 6-14)

  • Hormonal changes: Oestrogen levels gradually rise in the lead-up to ovulation, while progesterone remains low.

  • Microbiome impact: Rising oestrogen boosts Lactobacilli growth, lowering your vaginal pH back to its acidic state.

  • Infection risk: Your risk of infection lowers as Lactobacilli levels recover and strengthen your microbiome.

Ovulation (Around Day 14)

  • Hormonal changes: Oestrogen peaks, triggering the release of an egg and progesterone production.

  • Microbiome impact: The most stable and protective phase, where Lactobacilli thrive and your vaginal pH is most acidic.

  • Infection risk: Your risk of infection is at its lowest as Lactobacilli are at their strongest. 

Luteal Phase (Days 15-28)

  • Hormonal changes: Progesterone rises and remains high, while oestrogen dips slightly before a small rise. If pregnancy doesn’t occur, both hormones drop towards the end of the luteal phase.

  • Microbiome impact: Progesterone reduces glycogen, lowering Lactobacilli levels and allowing the vaginal pH to rise slightly.

  • Infection risk: Your risk of infection may be higher due to less Lactobacilli.

When Am I Most At Risk Of Infection?

Different infections thrive in different conditions, so your infection risk changes throughout your cycle. 

  • Bacterial Vaginosis (BV): More likely during menstruation and your late luteal phase when Lactobacilli levels drop. 

  • Vulvo Vaginal Candiasis (Thrush or Yeast Infections): More likely in your luteal phase when progesterone is high, creating an environment that allows Candida overgrowth.

  • Sexually Transmitted Infections (STIs): More likely during your luteal phase, when Lactobacilli levels are lower.  

Your risk of infection remains lowest around ovulation, when Lactobacilli levels are at their highest and your vaginal microbiome is most protected.  

How Does Contraception Impact My Vaginal Microbiome? 

Hormonal contraception contains synthetic hormones that alter your natural levels and control your menstrual cycle. Research into the direct impact of contraception on your vaginal microbiome is still in its early stages but current studies suggest:

  • Oestrogen-based contraceptives (like the combined pill, the Mirena IUD, and the patch) may help maintain Lactobacilli levels and reduce your risk of infections like BV.

  • Progestin-only methods (like the mini pill or progestin IUS) could have the opposite effect, reducing Lactobacilli levels, while increasing your risk of infection. 

Everyone reacts differently to hormonal contraception. Always speak to your doctor about your personal health history to explore the best contraceptive option for you. 

Learning To Track Your Patterns

Your vaginal microbiome naturally shifts with your menstrual cycle, influenced by rising and falling hormone levels. If you struggle with recurring vaginal infections, tracking your cycle and spotting any patterns might help you understand what’s going on down there. Recognising your body’s natural rhythms and knowing when you’re most at risk of infections can empower you to take proactive steps to support a healthy vaginal microbiome


Sources: 

  1. NHS: Sexually Transmitted Infections (STIs)
  2. NHS: Bacterial Vaginosis 
  3. NHS: Thrush
  4. Protective Mechanisms of Vaginal Lactobacilli against Sexually Transmitted Viral Infections
  5. StatPearls: Estrogen
  6. The healthy female microbiome across body sites: effect of hormonal contraceptives and the menstrual cycle
  7. Guideline: Vulvovaginal candidosis
  8. Daily Vaginal Microbiota Fluctuations Associated with Natural Hormonal Cycle, Contraceptives, Diet, and Exercise
  9. Vaginal microbiome: normalcy vs dysbiosis